It also greatly improved yields in germ line mutations.
2.
Germ line mutations in DNA repair genes cause only 2 5 % of colon cancer cases.
3.
These germ line mutations are indicated in a box at the left of the figure with an arrow indicating their contribution to DNA repair deficiency.
4.
For instance two dominant-negative germ line mutations were identified in the Ataxia telangiectasia mutated ( ATM ) gene which increases susceptibility to breast cancer.
5.
Some germ line mutations in DNA repair genes cause up to 100 % lifetime chance of cancer ( e . g ., p53 mutations ).
6.
Such germ line mutations are shown in a box at the left of the figure, with an indication of their contribution to DNA repair deficiency.
7.
Individuals with a germ line mutation causing deficiency in any of 34 DNA repair genes ( see article DNA repair-deficiency disorder ) are at increased risk of cancer.
8.
These mutations, which are identical to the ones present in SGS as germ line mutations, impair the degradation of SETBP1 and therefore cause increased cellular levels of the protein.
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